Next CERIC Seminar
May 29th CMM Lecture Hall (L8:00)
Speaker: Erez Lieberman Aiden, Department of Genetics, Baylor College of Medicine
Title: A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping
Host: Jesper Tegnér
miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development
Lars Maegdefessel, Joshua M. Spin, Uwe Raaz, Suzanne M. Eken, Ryuji Toh, Junya Azuma, Matti Adam, Futoshi Nagakami, Helen M. Heymann, Ekaterina Chernugobova, Hong Jin, Joy Roy, Rebecka Hultgren, Kenneth Caidahl, Sonja Schrepfer, Anders Hamsten, Per Eriksson, Michael V. McConnell, Ronald L. Dalman and Philip S. Tsao. Nature Communications 5:5214 (2014).
CERIC's goal is to be an internationally leading center in chronic inflammation, the pathological process that links inflammatory disorders such as multiple sclerosis, rheumatoid arthritis and psoriasis with atherosclerotic cardiovascular disease. For this purpose, we will build on existing, strong research in inflammatory mediators, autoimmunity , chronic inflammatory diseases, and cardiovascular disease at the Karolinska Institutet.
The following research aims will be addressed:
Aim 1: To determine why chronic inflammation sometimes, but not always, results in increased atherosclerosis and leads to myocardial infarction or stroke (cardiovascular disease).
Aim 2: To identify novel therapy targets and investigate the effects of targeted therapies against chronic inflammatory diseases and cardiovascualr diseases
Taken together, these two approaches will allow us to both understand the etiology and pathogenesis of chronic inflammatory diseases and cardiovascular disease and provide a basis for improved prevention and therapy for chronic inflammatory diseases and inflammatory cardiovascular disease, two major challenges to health in the population.