Next CERIC Seminar
September 5th CMM Lecture Hall (L8:00)
Speaker: Katey Rayner University of Ottawa Heart Institute
Title: microRNAs in atherosclerosis and lipid metabolism
Host: Lars Maegdefessel
Epitope-specific antibody response is controlled by immunoglobulin VH polymorphisms
Bruno Raposo, Doreen Dobritzsch, Changrong Ge, Diana Ekman, Bingze Xu, Ingrid Lindh, Michael Förster, Hüseyin Uysal, Kutty Selva Nandakumar, Gunter Schneider, and Rikard Holmdahl. The Journal of Experimental Medicine 211(3):405-411 (2014).
CERIC's goal is to be an internationally leading center in chronic inflammation, the pathological process that links inflammatory disorders such as multiple sclerosis, rheumatoid arthritis and psoriasis with atherosclerotic cardiovascular disease. For this purpose, we will build on existing, strong research in inflammatory mediators, autoimmunity , chronic inflammatory diseases, and cardiovascular disease at the Karolinska Institutet.
The following research aims will be addressed:
Aim 1: To determine why chronic inflammation sometimes, but not always, results in increased atherosclerosis and leads to myocardial infarction or stroke (cardiovascular disease).
Aim 2: To identify novel therapy targets and investigate the effects of targeted therapies against chronic inflammatory diseases and cardiovascualr diseases
Taken together, these two approaches will allow us to both understand the etiology and pathogenesis of chronic inflammatory diseases and cardiovascular disease and provide a basis for improved prevention and therapy for chronic inflammatory diseases and inflammatory cardiovascular disease, two major challenges to health in the population.