Next CERIC Seminar
June 3rd CMM Lecture Hall (L8:00)
Speaker: Iain McInnes, University of Glasgow
Title: Mechanisms driving chronicity in rheumatory arthritis
Host: Marie Wahren-Herlenius
New postdoctoral researcher initiative with the funding of 13 different post-doctoral positions.
The projects are spread across the research interests of the CERIC faculty and represent a range of investigations into the nature of inflammation and its role in disease.
- All the projects (click to expand)Open or Close
1. Magnus Bäck and Per Eriksson
Inflammation Resolution in Aortic Stenosis and Atherosclerosis
2. Jesper Haeggström and Craig Wheelock
The role of lipid mediators in determining macrophage phenotype in relation to immunometabolic processes driving chronic low-grade inflammation
3. Helena Erlandsson Harris and Birgitta Agerberth
The Alarmins HMGB1 and LL-37 as mediators of inflammation
4. Tomas Olsson, Marie Wahren-Herlenius, and Lars Fugger
Functional impact of genetic polymorphisms in inflammatory disorders
5. Göran K Hansson and Lars Maegdefessel
Acetylcholine Release from Choline Acetyltransferase+ T cells in Regulation of Vascular Inflammation
6. Anders Hamsten and Johan Askling
Genetic evaluation of the role of PCSK9 in inflammation and cardiovascular disease
7. Rikard Holmdahl
Structural analysis of immune response molecules involved in arthritis and atherosclerosis
8. Stephen Malin
The pathological and protective functions of B-lymphocytes in autoimmune diseases
9. Vivianne Malmström
Analysis of datasets from mass cytometry and from single cell RNA seq of lymphocytes, with special focus on generation of full length B and T cell receptor sequences
10. Thomas Renné
Mechanism and therapy for hereditary angioedema type II
11. Mona Ståhle
Exploring the molecular and cellular interactions between skin and adipose tissue in Psoriasis
12. Cecilia Söderberg-Nauclér
Does virus induced changes in cellular metabolism link inflammation to atherosclerosis?
13. Jesper Tegnér
From molecular pathways controlling induction of human T-regulatory cells to their clinical relevance
CERIC's goal is to be an internationally leading center in chronic inflammation, the pathological process that links inflammatory disorders such as multiple sclerosis, rheumatoid arthritis and psoriasis with atherosclerotic cardiovascular disease. For this purpose, we will build on existing, strong research in inflammatory mediators, autoimmunity , chronic inflammatory diseases, and cardiovascular disease at the Karolinska Institutet.
The following research aims will be addressed:
Aim 1: To determine why chronic inflammation sometimes, but not always, results in increased atherosclerosis and leads to myocardial infarction or stroke (cardiovascular disease).
Aim 2: To identify novel therapy targets and investigate the effects of targeted therapies against chronic inflammatory diseases and cardiovascualr diseases
Taken together, these two approaches will allow us to both understand the etiology and pathogenesis of chronic inflammatory diseases and cardiovascular disease and provide a basis for improved prevention and therapy for chronic inflammatory diseases and inflammatory cardiovascular disease, two major challenges to health in the population.