CERIC Center of Excellence for Research on Inflammation and Cardiovascular disease

CERIC is a Linné Center supported by the Swedish Research Council (Vetenskapsrådet)

 

Next CERIC Seminar

November 28th CMM Lecture Hall (L8:00)


Speaker: Elias Arnér, Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet 
Title: The Selenoprotein Thioredoxin Reductase 1 in Oxidative Stress and Cellular Signaling Pathways
Host: Rikard Holmdahl

 

Featured Publication

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Plasma contact system activation drives anaphylaxis in severe mast cell-mediated allergic reactions

Anna Sala-Cunill, Jenny Björkqvist, Riccardo Senter, Mar Guilarte, Victoria Cardona, Moises Labrador, Katrin F. Nickel, Lynn Butler, Olga Luengo, Parvin Kumar, Linda Labberton, Andy Long, Antonio Di Gennaro, Ellinor Kenne, Anne Jämsä, Thorsten Krieger, Hartmut Schlüter, Tobias Fuchs, Stefanie Flohr, Ulrich Hassiepen, Frederic Cumin, Keith McCrae, Coen Maas, Evi Stavrou, and Thomas Renné. Journal of Allergy and Clinical Immunology pii: S0091-6749(14)01111-7. doi: 10.1016/j.jaci.2014.07.057
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CERIC's goal is to be an internationally leading center in chronic inflammation, the pathological process that links inflammatory disorders such as multiple sclerosis, rheumatoid arthritis and psoriasis with atherosclerotic cardiovascular disease. For this purpose, we will build on existing, strong research in inflammatory mediators, autoimmunity , chronic inflammatory diseases, and cardiovascular disease at the Karolinska Institutet.

The following research aims will be addressed:



Aim 1: To determine why chronic inflammation sometimes, but not always, results in increased atherosclerosis and leads to myocardial infarction or stroke (cardiovascular disease).

Aim 2: To identify novel therapy targets and investigate the effects of targeted therapies against chronic inflammatory diseases and cardiovascualr diseases

Taken together, these two approaches will allow us to both understand the etiology and pathogenesis of chronic inflammatory diseases and cardiovascular disease and provide a basis for improved prevention and therapy for chronic inflammatory diseases and inflammatory cardiovascular disease, two major challenges to health in the population.

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